ATTENTION!

• There should be a minimum of eight hours between doses of this medicine.

• You should drink a small amount of water before taking this medicine to help it to dissolve under the tongue. The tablet should then be placed under the tongue and allowed to dissolve. If any of the tablet remains after 20 minutes it may be swallowed.

• This medicine may uncommonly cause fainting. People normally experience warning symptoms of this, such as nausea, vomiting, pallor, sweating, hot flushes and dizziness or lightheadedness. If you experience these symptoms, you should not attempt to stand up - lie down and raise your legs until the symptoms pass.

• This medicine may cause dizziness and lightheadedness and because of this, you should not drive or operate machinery for at least two hours after taking the medicine, or until the symptoms pass.

• If this medicine is taken with alcohol there is an increased risk of a drop in blood pressure. In addition, alcohol can impair sexual performance.

Use with caution in

• Decreased kidney function

• Decreased liver function

• Elderly people

• History of drops in blood pressure when moving from sitting to standing, which causes dizziness (postural hypotension)

• Low blood pressure (hypotension)

• Physical abnormality of the penis, such as severe curvature, scarring or Peyronie's disease

• Uncontrolled high blood pressure (hypertension)

Not to be used in

• Conditions in which sexual activity is not advisable, for example severe heart disorders

• Extremely low blood pressure (severe hypotension)

• People who have recently had a heart attack

• Severe angina not controlled by medical treatment (severe unstable angina)

• Severe heart failure

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby.Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

• This medicine is for use by men only. It should not be taken by pregnant or breastfeeding women.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

• Headache

• Nausea

• Sweating

• Dizziness

• Inflammation of the throat (pharyngitis)

• Flushing

• Alteration in taste

• Yawning

• Sleepiness (somnolence)

• Inflammation of the lining of the nose (rhinitis)

• Cough

• Fainting (syncope)

• Pain

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
 

How can this medicine affect other medicines?

If apomorphine is taken with nitrate medicines it may produce a drop in blood pressure resulting in dizziness. Tell your doctor if you are taking any of the following:
- glyceryl trinitrate
- isosorbide mononitrate
- isosorbide dinitrate
- amyl nitrate, also known as "poppers".

This medicine can be taken safely with the anti-sickness medicines domperidone, ondansetron and prochlorperazine, but other anti-sickness medicines are not recommended as they have not been studied with this medicine.

This medicine should not be taken with other medicines that increase dopamine activity in the brain and nervous system (dopamine agonists), as this increases the chance of side effects. These medicines include:
- certain treatments for Parkinson's disease, eg bromocriptine, cabergoline, apomorphine, amantadine, levodopa, entacapone, pergolide, lisuride, pramiprexole, ropinirole, selegiline.
- quinagolide.

This medicine should not be taken with medicines that decrease dopamine activity in the brain and nervous system (dopamine antagonists), as the effect of either medicine may be reduced. Dopamine antagonists include:
- antipsychotic medicines.

If this medicine is taken with alcohol there is an increased risk of a drop in blood pressure. In addition, alcohol can impair sexual performance.